The Hypothalamic Circuit That DESTROYS Fertility (How to Hack It)

October 06, 2025

Code to Conception

Daily micro-protocols for the 90-day miracle window

| October 6, 2025 |

🔬 Pre-Bump Biology  

 Your fertility lives or dies by a tiny hypothalamic “pulse-generator” in the arcuate nucleus—the KNDy network (kisspeptin, neurokinin B, dynorphin). When stress (CRH), low energy/low leptin, high prolactin, or circadian chaos jam this circuit, GnRH pulses flatten, LH/FSH misfire, ovulation stalls, testosterone drifts off-track, and time-to-pregnancy lengthens. Fix the inputs, restore the pulses—fast.

🧬 Protocol Drop  

 Today’s 1-Step Protocol:
Lock your circadian anchor for the next 14 nights: sleep 7.5–9 h with fixed bed/wake times (±30 min), outdoor morning light 30–60 min within 1 h of waking, and no bright screens in the last 3 h before bed. If needed (not pregnant), take melatonin 3 mg 60–90 min pre-bed for 6–8 weeks. This single move normalizes SCN → KNDy timing and improves fecundability within weeks.

👉 Read the full study summary

📚 Glossary Pop  

 KNDy Neurons: A trio in the arcuate nucleus—Kisspeptin starts GnRH/LH pulses, Neurokinin B synchronizes pulse onset, Dynorphin stops the pulse. Think metronome: too slow or too fast and the whole reproductive orchestra (egg maturation, ovulation, testosterone production) falls out of rhythm.

Text your partner your bedtime and wake time for tonight. Two calendars, one clock. Pulse perfection starts with lights out.
P.S. Tomorrow Teaser
Your labs may look like they’re slipping in the wrong direction—but that doesn’t mean the story is over. New clinical evidence shows you can reset core reproductive signals in just 12 weeks, restoring balance and improving outcomes that matter most. Tomorrow, I’ll walk you through the exact playbook.

Want to learn more?

Fraser, G. L., Obermayer-Pietsch, B., Laven, J., et al. (2021). Randomized controlled trial of the NK3R antagonist fezolinetant in PCOS. Journal of Clinical Endocrinology & Metabolism, 106(9), e3519–e3532. https://doi.org/10.1210/clinem/dgab320

Hoskova, K., Kayton, B. N., Chen, M. E., et al. (2022). Kisspeptin overcomes hyperprolactinemia-induced GnRH suppression in humans. Journal of Clinical Endocrinology & Metabolism, 107(8), e3515–e3525. https://doi.org/10.1210/clinem/dgac151

Michopoulos, V., Mancini, F., Loucks, T. L., & Berga, S. L. (2013). Neuroendocrine recovery with CBT in functional hypothalamic amenorrhea. Fertility and Sterility, 99(7), 2084–2091.e1. https://doi.org/10.1016/j.fertnstert.2013.02.036

Zhang, Y., et al. (2025). Preconception sleep behaviors and fecundability: Prospective cohort. Reproductive Health, 22. https://doi.org/10.1186/s12978-025-02106-x

Shafie, A., Aleyasin, A., et al. (2024). Astaxanthin improves oocyte and embryo quality in POR: RCT. Journal of Ovarian Research, 17, 212. https://doi.org/10.1186/s13048-024-01537-7

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