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The Folate Form That ANNIHILATES Male Infertility (Doctors Don't Know This)

October 08, 2025

Code to Conception

Daily micro-protocols for the 90-day miracle window

| October 8, 2025 |

🔬 Pre-Bump Biology  

Male infertility is often traced back to one critical bottleneck: broken methylation cycles that damage sperm DNA. Folate—especially in its active form, 5-MTHF—restores one-carbon metabolism, lowering homocysteine and boosting DNA methylation. In just 90 days, this shift can cut sperm DNA fragmentation and dramatically increase pregnancy chances in ART.  

🧬 Protocol Drop  

Today’s 1-Step Protocol:  

Take 5-MTHF 800 µg every morning with breakfast for 12 weeks. Pair it with riboflavin (1.6 mg), vitamin B12 (500–1,000 µg), and vitamin B6 (2–10 mg). This stack stabilizes methylation, lowers homocysteine, and primes sperm for the next full spermatogenic cycle.  

👉 Read the full study summary

📚 Glossary Pop  

DNA Fragmentation Index (DFI): A lab measure of how many sperm carry broken DNA strands. Higher DFI means embryos are less likely to implant and more likely to miscarry. Lowering DFI through nutrition, lifestyle, or targeted supplements directly improves fertility odds.  

Send this micro-protocol to your partner tonight—his next 90 days could make or break your shared fertility journey.
P.S. Tomorrow Teaser
Think stress only messes with your mood? New evidence shows anxiety directly hijacks the brain’s pulse-generator that controls ovulation. Missed surges mean missed eggs—and missed chances at conception. Tomorrow, we’ll reveal the exact neural circuit and the 1 habit that can reset it.

Want to learn more?

Schisterman, E. F., Sjaarda, L. A., Clemons, T., et al. (2020). Effect of folic acid and zinc supplementation in men on semen quality and live birth among couples undergoing infertility treatment: A randomized clinical trial. JAMA, 323(1), 35–48. https://doi.org/10.1001/jama.2019.18714 

Dellino, M., Minoia, C., De Palo, R., et al. (2021). High dosage folic acid supplementation in male infertility is potentially beneficial for ICSI outcomes and decreases sperm DNA fragmentation. Journal of Clinical Medicine, 10(13), 2961. https://doi.org/10.3390/jcm10132961 

Li, X., Zeng, Y.-M., Luo, Y.-d., et al. (2023). Effects of folic acid and folic acid plus zinc supplements on sperm characteristics and pregnancy outcomes of infertile men: A systematic review and meta-analysis. Heliyon, 9(7), e18224. https://doi.org/10.1016/j.heliyon.2023.e18224 

Wang, W., Cui, K., Zhang, H., et al. (2025). Causal association between folate and male infertility: A Mendelian randomization study. World Journal of Men’s Health. https://doi.org/10.5534/wjmh.240252 

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