The Core Rebuild: How 5-MTHF and Vitamin D3 Shape Conception

October 12, 2025

Code to Conception

Daily micro-protocols for the 90-day miracle window

Day 2 of 90

| October 12, 2025 |

🔬 Pre-Bump Biology  

You’ll stack one-carbon power with mitochondrial light. 5-MTHF + vitamin D₃ drives DNA methylation and endometrial receptivity (think HOXA10), while near-infrared PBM energizes pelvic mitochondria and microcirculation. Together, they target three make-or-break outcomes: egg/sperm quality, implantation readiness, and lower miscarriage risk through inflammation control and homocysteine reduction.

🧬 Protocol Drop  

Today’s Allopathic Protocol:
Take 400 µg 5-MTHF + 2,000 IU vitamin D₃ once daily with your fattiest meal. Continue for ≥90 days. Aim for 25(OH)D = 30–50 ng/mL; add B12 (250–500 µg methylcobalamin) if B12 is low/unknown.

Today’s Holistic Protocol:
Run near-infrared PBM (≈850 nm) over the lower abdomen at ~5–10 J/cm² per point, covering uterus/ovaries, 3×/week for 6–8 weeks before attempts/transfer. Total session ≈ 10–15 minutes. Pause once pregnancy is possible.

👉 Read the summary on methyl-folate + vitamin D₃.
👉 Read the summary on red/NIR pelvic PBM.

📚 Glossary Pop  

HOXA10: A master gene that programs the uterine lining to become receptive so an embryo can implant. Vitamin D signaling up-regulates HOXA10, improving the chances that a healthy embryo “sticks.”

Stack it: take your dose with dinner, then do tonight’s 15-minute PBM. Consistency compounds.
P.S. Tomorrow Teaser
Tomorrow’s double-header hits male fertility from two flanks: power and temperature. You’ll learn how CoQ10 (200 mg × 2/day) supercharges sperm mitochondria for faster, stronger swimmers—while nightly 15-minute cooling keeps testicular temps in the sweet zone for DNA-intact, high-motility sperm. Energy meets precision.

Want to learn more?

Baldini, G. M., Meng, X., Wang, K., & van Tienhoven-Wind, X. A. (2024). Effect of vitamin D supplementation on in vitro fertilization outcomes: A trial-sequential meta-analysis of randomized controlled trials. Frontiers in Endocrinology, 15, 11147876. https://doi.org/10.3389/fendo.2024.11147876

Samaniego-Vaesken, M. L., Alonso-Aperte, E., & Varela-Moreiras, G. (2024). Supplementation with folic acid or 5-methyltetrahydrofolate and neural tube defect prevention: An evidence-based review. Nutrients, 16(2), 333. https://doi.org/10.3390/nu16020333

Pludowski, P., Holick, M. F., & Pilz, S. (2024). Vitamin D supplementation: Evidence-based dosing and monitoring recommendations. Nutrients, 16(2), 259. https://doi.org/10.3390/nu16020259

Jafarabadi, M., Farbod, Y., & Shariat, M. (2024). Low-level laser therapy for improvement of IVF outcomes in patients with recurrent implantation failure: A randomized clinical trial. Journal of Lasers in Medical Sciences, 15, e15. https://doi.org/10.34172/jlms.2024.15

Stigliani, S., Persico, G. G., & Balbi, M. (2024). The power of 810-nm near-infrared photobiomodulation therapy for human asthenozoospermia. Scientific Reports, 14, 14321. https://doi.org/10.1038/s41598-024-77823-7

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